Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.42 |
| ▸ | CA9 | Q16790 | 6/20 | 0.42 |
| ▸ | CA12 | O43570 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 5/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | ENPP3 | O14638 | 4/20 | 0.37 |
| ▸ | GPR174 | Q9BXC1 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27576857 | 0.85 | LMNA (0.34) | CA2CA9CA12CA1LMNA | |
| SCHEMBL27564358 | 0.79 | PTGS1 (0.43) | PTGS1PTGS2LMNATP53 | |
| SCHEMBL27561385 | 0.78 | TDP1 (0.38) | PTGS1PTGS2THRB | |
| SCHEMBL27582103 | 0.78 | KDR (0.40) | — | |
| SCHEMBL27561508 | 0.78 | POLB (0.47) | CA2CA9CA12CA1TNNI3K | |
| SCHEMBL27582099 | 0.76 | CA2 (0.50) | CA2CA9CA12CA1CA7 | |
| SCHEMBL27561403 | 0.75 | PTGS1 (0.40) | PTGS1PTGS2LMNATP53 | |
| SCHEMBL27564357 | 0.75 | ALDH3A1 (0.46) | LMNATP53 | |
| SCHEMBL7247542 | 0.73 | MAPT (0.45) | PTGS1PTGS2BRD4 | |
| SCHEMBL27582110 | 0.73 | KDR (0.35) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |