Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.47 |
| ▸ | CA1 | P00915 | 12/20 | 0.47 |
| ▸ | CA9 | Q16790 | 6/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.40 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.39 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27585105 | 0.80 | IDO1 (0.40) | CA2IDO1 | |
| SCHEMBL5386714 | 0.73 | IDO1 (0.50) | IDO1 | |
| SCHEMBL8360359 | 0.73 | PDIA6 (0.51) | CA2CA1CA9CA12CA6 | |
| SCHEMBL5677981 | 0.72 | IDO1 (0.61) | IDO1 | |
| SCHEMBL27582099 | 0.70 | CA2 (0.50) | CA2CA1CA9CA12CA6 | |
| SCHEMBL27469367 | 0.69 | IDO1 (0.45) | IDO1 | |
| SCHEMBL27565258 | 0.69 | MEN1 (0.43) | IDO1 | |
| SCHEMBL7715685 | 0.69 | IDO1 (0.48) | IDO1 | |
| SCHEMBL20766620 | 0.69 | CA2 (0.62) | CA2CA1CA9CA12CA6 | |
| SCHEMBL7113890 | 0.69 | PTGS1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144372-A1 | SULPHOHYDROXAMIC ACIDS AND SULPHOHYDROXAMATES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000042002-A1 | SULPHOHYDROXAMIC ACIDS AND SULPHOHYDROXAMATES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |