Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454587 | 0.88 | HAO1 (0.48) | GRM5 | |
| SCHEMBL4460258 | 0.88 | GRM5 (0.50) | GRM5 | |
| SCHEMBL4457929 | 0.87 | GRM5 (0.56) | GRM5 | |
| SCHEMBL4456181 | 0.86 | CA12 (0.49) | GRM5 | |
| Benzonitrile SCHEMBL28071141 | 0.85 | TSHR (0.64) | TSHRGRM5 | |
| SCHEMBL6369908 | 0.85 | APP (0.60) | APPGRM5 | |
| SCHEMBL4451906 | 0.83 | GRM5 (0.44) | GRM5 | |
| SCHEMBL4454176 | 0.81 | ALDH1A1 (0.54) | GRM5 | |
| SCHEMBL4452362 | 0.80 | GRM5 (0.42) | GRM5 | |
| SCHEMBL4458314 | 0.80 | HAO1 (0.44) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3284736-B1 | FLUORINATION OF AROMATIC RING SYSTEMS | NUTECH VENTURES (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-3284736-A1 | FLUORINATION OF AROMATIC RING SYSTEMS | NUtech Ventures (US) | 2018-02-21 | — | — | EP | disclosed |
| EP-2537826-B1 | Fluorination of aromatic ring systems | NUTECH VENTURES (US) | 2017-03-08 | — | — | EP | disclosed |
| US-9302990-B2 | Fluorination of aromatic ring systems | NUTECH VENTURES (US) | 2016-04-05 | — | — | US | disclosed |
| US-9302990-B2 | Fluorination of aromatic ring systems | NUTECH VENTURES (US) | 2016-04-05 | — | — | US | disclosed |
| US-8546578-B2 | Iodonium Cyclophanes for SECURE arene functionalization | NUTECH VENTURES (US) | 2013-10-01 | — | — | US | disclosed |
| US-8546578-B2 | Iodonium Cyclophanes for SECURE arene functionalization | NUTECH VENTURES (US) | 2013-10-01 | — | — | US | disclosed |
| WO-2013003734-A2 | FLUORINATION OF AROMATIC RING SYSTEMS | NUTECH VENTURES (US) | 2013-01-03 | — | — | WO | disclosed |
| EP-2537826-A1 | Fluorination of aromatic ring systems | Nutech Ventures (US) | 2012-12-26 | — | — | EP | disclosed |
| US-20120004417-A1 | FLUORINATION OF AROMATIC RING SYSTEMS | NATIONAL SCIENCE FOUNDATION | 2012-01-05 | — | — | US | disclosed |
| US-20110313170-A1 | Fluorination of Aromatic Ring Systems | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2011-12-22 | — | — | US | disclosed |
| US-20110313170-A1 | Fluorination of Aromatic Ring Systems | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2011-12-22 | — | — | US | disclosed |
| US-20110190505-A1 | Iodonium Cyclophanes for SECURE Arene Functionalization | NATIONAL SCIENCE FOUNDATION | 2011-08-04 | — | — | US | disclosed |
| WO-2010048170-A2 | FLUORINATION OF AROMATIC RING SYSTEMS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2010-04-29 | — | — | WO | disclosed |
| US-20090306115-A1 | Phenyl ethyne compounds | MERCK SHARP & DOHME CORP. | 2009-12-10 | — | — | US | disclosed |
| US-20090306115-A1 | Phenyl ethyne compounds | MERCK SHARP & DOHME CORP. | 2009-12-10 | — | — | US | disclosed |
| EP-1874724-A2 | PHENYL ETHYNE COMPOUNDS | Merck & Co., Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006115895-A2 | PHENYL ETHYNE COMPOUNDS | MERCK & CO., INC. (US) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004417-A1 | FLUORINATION OF AROMATIC RING SYSTEMS | PFAS, SLC43A1, DDC | TSHR 592/4885APP 3262/4885GRM5 3724/4885 |
| US-20110190505-A1 | Iodonium Cyclophanes for SECURE Arene Functionalization | ABL1, SLC7A5, DDC | TSHR 929/4885APP 3196/4885GRM5 743/4885 |
| US-20090306115-A1 | Phenyl ethyne compounds | DDT, CHRM3, CBR3 | TSHR 356/4885APP 2084/4885GRM5 143/4885 |
| US-20110313170-A1 | Fluorination of Aromatic Ring Systems | PFAS, SLC43A1, DDC | TSHR 592/4885APP 3262/4885GRM5 3724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.