SCHEMBL27587159

SCHEMBL27587159

N#Cc1cc(-c2ccccc2)ccc1C(=O)O

nearest known ligand 0.58

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ACMSD Q8TDX5 3/20 0.58
HNF4A P41235 2/20 0.58
XDH P47989 2/20 0.54
SLC22A12 Q96S37 2/20 0.54
MCL1 Q07820 3/20 0.53
DHFR P00374 1/20 0.53
DCLRE1A Q6PJP8 1/20 0.51
DCLRE1B Q9H816 1/20 0.51
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
HPGD P15428 1/20 0.47
FABP7 O15540 1/20 0.46
FABP3 P05413 1/20 0.46
FABP5 Q01469 1/20 0.46
ACLY P53396 2/20 0.45
PTPN1 P18031 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6621629 0.98 ACMSD (0.56) ACMSDHNF4AXDHSLC22A12MCL1
SCHEMBL10401317 0.86 ACMSD (0.58) ACMSDHNF4AXDHSLC22A12MCL1
SCHEMBL29151909 0.85 MCL1 (0.59) ACMSDHNF4AXDHSLC22A12MCL1
SCHEMBL1095325 0.82 ACMSD (0.58) ACMSDHNF4AXDHSLC22A12MCL1
SCHEMBL28789058 0.81 AR (0.52) XDHSLC22A12ALDH1A1
Hydrochloric Acid SCHEMBL4352423 0.81 ACMSD (0.56) ACMSDHNF4AXDHSLC22A12MCL1
Water SCHEMBL29008379 0.79 ACMSD (0.68) ACMSDHNF4AMCL1DHFRDCLRE1A
SCHEMBL11666019 0.79 XDH (0.42) XDHSLC22A12MCL1KDM4EALDH1A1
SCHEMBL180853 0.77 ALDH1A1 (0.56) KDM4EALDH1A1HPGD
SCHEMBL68982 0.77 ACMSD (0.70) ACMSDHNF4AMCL1DHFRDCLRE1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114773249-A Compounds, pharmaceutical compositions and methods for treating inflammatory diseases 艾匹克治疗公司 2022-07-22 CN disclosed
CN-1556788-A Muscarinic agonists 2004-12-22 CN disclosed