SCHEMBL11666019

SCHEMBL11666019

C=CCc1ccc(-c2ccc(C(=O)O)c(C#N)c2)cc1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
XDH P47989 2/20 0.42
SLC22A12 Q96S37 2/20 0.42
RXRA P19793 1/20 0.41
RXRB P28702 1/20 0.41
RXRG P48443 1/20 0.41
PTGS2 P35354 1/20 0.40
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 2/20 0.39
GAA P10253 2/20 0.39
HPGD P15428 2/20 0.39
GLA P06280 1/20 0.39
RCE1 Q9Y256 1/20 0.39
ALOX12 P18054 1/20 0.37
MCL1 Q07820 1/20 0.37
RARB P10826 2/20 0.36
RARA P10276 1/20 0.36
RARG P13631 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2732866 0.88 XDH (0.42) XDHKDM4EALDH1A1GAAHPGD
SCHEMBL10432994 0.80 XDH (0.50) XDHRXRAKDM4EALDH1A1GAA
SCHEMBL7736559 0.80 RARB (0.56) XDHRXRAPTGS2KDM4EMCL1
SCHEMBL27587159 0.79 ACMSD (0.58) XDHSLC22A12KDM4EALDH1A1HPGD
SCHEMBL11668275 0.78 PTGS2 (0.43) XDHRXRARXRBRXRGPTGS2
Hydrochloric Acid SCHEMBL6621629 0.77 ACMSD (0.56) XDHSLC22A12KDM4EALDH1A1HPGD
SCHEMBL7213550 0.76 ALOX5 (0.43) XDHSLC22A12RXRAKDM4EALDH1A1
SCHEMBL11664824 0.74 RXRA (0.39) XDHRXRARXRBRXRGPTGS2
SCHEMBL11451867 0.73 MEN1 (0.45) XDH
SCHEMBL23045051 0.72 CA12 (0.43) XDHSLC22A12ALDH1A1RCE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4073742-A Cyano-substituted biphenyl compounds and liquid crystalline dielectrics containing the same MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1978-02-14 US disclosed