Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | ROS1 | P08922 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.42 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24096486 | 0.77 | SRC (0.50) | SRCEGFRPIK3CDDYRK3CDK1 | |
| SCHEMBL20553262 | 0.74 | SRC (0.42) | SRCEGFRDYRK3CDK1ROS1 | |
| SCHEMBL30405599 | 0.74 | SRC (0.42) | SRCEGFRDYRK3CDK1ROS1 | |
| SCHEMBL5801670 | 0.74 | KDM4E (0.41) | SRCEGFRPIK3CDDYRK3CDK1 | |
| SCHEMBL4819181 | 0.74 | NUDT14 (0.66) | SRCEGFRPIK3CDMAPK1LCK | |
| SCHEMBL27604499 | 0.73 | SRC (0.50) | SRCEGFRPIK3CDKDRPIK3CG | |
| SCHEMBL14693600 | 0.73 | XDH (0.46) | SRCPIK3CDDYRK3CDK1ROS1 | |
| SCHEMBL401337 | 0.72 | SRC (0.45) | SRCEGFRPIK3CDDYRK3CDK1 | |
| SCHEMBL4825966 | 0.71 | SRC (0.43) | SRCEGFRPIK3CDDYRK3CDK1 | |
| SCHEMBL3876328 | 0.71 | KDM4E (0.66) | EGFRGSK3BCYP17A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1520298-A | Pyrazolopyrimidines as therapeutic agents | �����ʩ���عɷݹ�˾ | 2004-08-11 | — | — | CN | disclosed |
| CN-1390219-A | Pyrazolopyrimidines as therapeutic agents | ABBOTT AG (DE) | 2003-01-08 | — | — | CN | disclosed |