Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | ROS1 | P08922 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.42 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20553262 | 1.00 | SRC (0.42) | SRCCSNK1A1CSNK1DCDK5CLK4 | |
| SCHEMBL4825966 | 0.80 | SRC (0.43) | SRCCSNK1A1CSNK1DCDK5CLK4 | |
| SCHEMBL27587387 | 0.74 | SRC (0.45) | SRCCSNK1A1CSNK1DCDK5CLK4 | |
| SCHEMBL23150443 | 0.73 | JAK2 (0.42) | SRCCSNK1A1CSNK1DCDK5CLK4 | |
| SCHEMBL401337 | 0.72 | SRC (0.45) | SRCCSNK1A1CSNK1DCDK5CLK4 | |
| SCHEMBL24096486 | 0.71 | SRC (0.50) | SRCCSNK1A1CSNK1DCDK5CLK4 | |
| SCHEMBL22748995 | 0.70 | DYRK3 (0.51) | SRCCSNK1A1CSNK1DCDK5CLK4 | |
| SCHEMBL22430336 | 0.70 | ADK (0.51) | SRCCSNK1A1CSNK1DCDK5CLK4 | |
| SCHEMBL26809032 | 0.70 | DYRK3 (0.55) | SRCCSNK1A1CSNK1DCDK5CLK4 | |
| SCHEMBL130592 | 0.68 | SRC (0.50) | SRCCSNK1A1CSNK1DCDK5CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |