Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27596205 | 0.90 | MAPK14 (0.43) | TOP2AMAPK14L3MBTL1 | |
| SCHEMBL27596213 | 0.89 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27596179 | 0.89 | MAPK13 (0.43) | TOP2AMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27615061 | 0.88 | LIMK1 (0.41) | TOP2AL3MBTL1 | |
| SCHEMBL27596405 | 0.87 | MAPK14 (0.38) | TOP2AMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27596183 | 0.83 | ALDH1A1 (0.40) | L3MBTL1NPC1RAB9A | |
| SCHEMBL27596180 | 0.83 | LIMK1 (0.40) | MAPK14 | |
| SCHEMBL5568870 | 0.82 | POLB (0.44) | MAPK14MAPK13MAPK12MAPK11L3MBTL1 | |
| SCHEMBL27596169 | 0.81 | MAPK14 (0.38) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5564247 | 0.81 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |