Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27596205 | 0.89 | MAPK14 (0.43) | MAPK14TOP2ALCK | |
| SCHEMBL27596165 | 0.87 | TOP2A (0.40) | MAPK14TOP2ANPC1MAPK13MAPK12 | |
| SCHEMBL27596179 | 0.86 | MAPK13 (0.43) | MAPK14TOP2AMAPK13MAPK12MAPK11 | |
| SCHEMBL27596213 | 0.86 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27596180 | 0.85 | LIMK1 (0.40) | MAPK14TMPRSS15LCK | |
| SCHEMBL27615061 | 0.84 | LIMK1 (0.41) | TOP2A | |
| SCHEMBL5568716 | 0.81 | P2RX7 (0.45) | MAPK14NPC1P2RX7MAPK13MAPK12 | |
| SCHEMBL27614968 | 0.80 | ALDH1A1 (0.41) | MAPK14TOP2ATMPRSS15ALDH1A1LCK | |
| SCHEMBL5568753 | 0.79 | P2RX7 (0.45) | MAPK14TMPRSS15P2RX7MAPK13MAPK12 | |
| SCHEMBL5568609 | 0.74 | RAB9A (0.49) | MAPK14NPC1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |