Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27596199 | 0.90 | LCK (0.41) | MAPK14MAPK13MAPK12MAPK11TDP1 | |
| SCHEMBL27596189 | 0.86 | MAPK13 (0.37) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27596184 | 0.83 | LCK (0.36) | MAPK14LCKPKM | |
| SCHEMBL27596165 | 0.81 | TOP2A (0.40) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5564649 | 0.80 | EPHX1 (0.45) | — | |
| SCHEMBL27596183 | 0.80 | ALDH1A1 (0.40) | — | |
| SCHEMBL5564247 | 0.78 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27615016 | 0.76 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5568870 | 0.75 | POLB (0.44) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5564238 | 0.74 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |