Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27596169 | 0.90 | MAPK14 (0.38) | LCKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27596184 | 0.89 | LCK (0.36) | LCKMAPK14ALDH1A1PKM | |
| SCHEMBL27596189 | 0.87 | MAPK13 (0.37) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27596205 | 0.80 | MAPK14 (0.43) | LCKMAPK14 | |
| SCHEMBL5568246 | 0.80 | NPC1 (0.47) | NPC1RAB9A | |
| SCHEMBL27596193 | 0.79 | PKM (0.44) | LCKMAPK14NPC1RAB9AALDH1A1 | |
| SCHEMBL27614981 | 0.79 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL27615012 | 0.78 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5563877 | 0.78 | NPC1 (0.46) | LCKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5564741 | 0.78 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |