Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 3/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27596191 | 0.90 | HTT (0.44) | CTNNB1WNT3AALDH1A1LMNAGLA | |
| SCHEMBL27596193 | 0.89 | PKM (0.44) | MAPK14RAB9ACTNNB1WNT3AALDH1A1 | |
| SCHEMBL27596328 | 0.89 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14ABL1 | |
| SCHEMBL27596183 | 0.88 | ALDH1A1 (0.40) | ABL1RAB9AALDH1A1LMNANPC1 | |
| SCHEMBL27596179 | 0.81 | MAPK13 (0.43) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5568947 | 0.80 | MAPK13 (0.52) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL27614965 | 0.80 | ALDH1A1 (0.44) | MAPK14RAB9AALDH1A1LMNANPC1 | |
| SCHEMBL5568944 | 0.75 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14RAB9A | |
| SCHEMBL5563661 | 0.74 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14RAB9A | |
| SCHEMBL5564819 | 0.73 | MAPK13 (0.44) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |