Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5975118 | 0.86 | CCR3 (0.57) | ACHECCR3SIGMAR1HTR2ADRD2 | |
| SCHEMBL5974931 | 0.86 | CCR3 (0.57) | ACHECCR3SIGMAR1HTR2ADRD2 | |
| SCHEMBL5974936 | 0.86 | CCR3 (0.57) | ACHECCR3SIGMAR1HTR2ADRD2 | |
| SCHEMBL31288163 | 0.85 | ACHE (0.53) | ACHECCR3SIGMAR1HTR2ADRD2 | |
| Hydrochloric Acid SCHEMBL6660125 | 0.85 | CCR3 (0.55) | ACHECCR3SIGMAR1HTR2ADRD2 | |
| SCHEMBL3572183 | 0.82 | MEN1 (0.48) | ACHECCR3SIGMAR1DRD2DRD4 | |
| SCHEMBL11178158 | 0.81 | DRD2 (0.49) | ACHECCR3SIGMAR1HTR2ADRD2 | |
| SCHEMBL995393 | 0.80 | ACHE (0.50) | ACHESIGMAR1 | |
| SCHEMBL5974372 | 0.79 | LMNA (0.55) | ACHECCR3SIGMAR1HTR2ADRD2 | |
| SCHEMBL5974378 | 0.79 | LMNA (0.55) | ACHECCR3SIGMAR1HTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699008-A | Sulfamide derivative and pharmaceutical composition containing it | EA制药株式会社 | 2018-10-23 | — | — | CN | disclosed |
| CN-104540826-B | Spiro-fused piperidine derivatives useful as inhibitors of extrarenal potassium channels | 默沙东公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-107459508-A | Annelated pyrimidines as the inhibitor of P97 compounds | 克里弗生物科学公司 | 2017-12-12 | — | — | CN | disclosed |
| CN-101434596-A | Novel azaheterocyclic amides useful for treating pain | ABBOTT LAB (US) | 2009-05-20 | — | — | CN | disclosed |
| CN-1849315-A | Novel nitrogen-containing heterocyclic amides for the treatment of pain | ABBOTT LAB (US) | 2006-10-18 | — | — | CN | disclosed |
| CN-1826334-A | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | MERCK & CO INC (US) | 2006-08-30 | — | — | CN | disclosed |
| CN-1481377-A | Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteinases and TNF-alpha | ����˹�ж�-����˹˹����ҩƷ��˾ | 2004-03-10 | — | — | CN | disclosed |