Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | PMM2 | O15305 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12239458 | 0.77 | TRPA1 (0.35) | SMN1; SMN2KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL16502301 | 0.72 | ACHE (0.35) | SMN1; SMN2KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL1022418 | 0.72 | CYP3A4 (0.63) | SMN1; SMN2KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL11387301 | 0.70 | TSHR (0.41) | SMN1; SMN2KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL1020719 | 0.68 | ALDH1A1 (0.46) | SMN1; SMN2KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL29401800 | 0.68 | ALDH1A1 (0.46) | SMN1; SMN2KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL28108539 | 0.68 | MAPT (0.36) | SMN1; SMN2KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL11057456 | 0.67 | NPC1 (0.46) | SMN1; SMN2KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL20117456 | 0.65 | MEN1 (0.31) | SMN1; SMN2KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL3924020 | 0.65 | HDAC4 (0.35) | SMN1; SMN2KMT2ANPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100369899-C | Substituted indazoles with anti-cancer activity | AVENTIS PHARMA SA (FR) | 2008-02-20 | — | — | CN | disclosed |
| CN-1642922-A | Substituted indazoles with anti-cancer activity | AVENTIS PHARMA SA (FR) | 2005-07-20 | — | — | CN | disclosed |