Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061503 | 0.75 | BACE1 (0.39) | CNR1CNR2HPGDALDH1A1MAPT | |
| SCHEMBL8634675 | 0.74 | TSHR (0.56) | CNR1CNR2HPGDALDH1A1MAPT | |
| SCHEMBL1642904 | 0.64 | HTT (0.50) | HPGDALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL2806112 | 0.64 | HTT (0.50) | HPGDALDH1A1MAPTSMN1; SMN2KDM4E | |
| Ammonia Solution, Strong SCHEMBL23877941 | 0.63 | HTT (0.49) | HPGDALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL10241255 | 0.63 | RIPK1 (0.50) | ALDH1A1KDM4EPOLBHTTTHRB | |
| SCHEMBL1498696 | 0.62 | GAA (0.50) | CNR1CNR2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3218735 | 0.62 | CACNA1B (0.58) | HPGDALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL13698663 | 0.62 | RIPK1 (0.45) | CNR1CNR2HPGDALDH1A1MAPT | |
| SCHEMBL12911312 | 0.61 | CA2 (0.42) | ALDH1A1MEN1KMT2ASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100519550-C | 2-oxoindole compounds having inhibitory activity on glycogen synthase kinase 3 receptor | ASTRAZENECA AB SE (SE) | 2009-07-29 | — | — | CN | disclosed |
| CN-1923812-A | New compounds | ASTRAZENECA AB (SE) | 2007-03-07 | — | — | CN | disclosed |
| CN-1642938-A | Novel compounds | ASTRAZENECA AB (SE) | 2005-07-20 | — | — | CN | disclosed |