Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.74 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.51 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | ATR | Q13535 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.49 |
| ▸ | BPTF | Q12830 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1199415 | 0.83 | PLD1 (0.60) | CNR2PLD1HDAC1HDAC2GPR119 | |
| SCHEMBL3442195 | 0.81 | GPR119 (0.59) | PLD1HDAC2HTR7HTR1AGPR119 | |
| SCHEMBL30443428 | 0.81 | PLD1 (0.61) | CNR2PLD1HDAC1HDAC2HTR7 | |
| SCHEMBL29022049 | 0.81 | PLD1 (0.61) | CNR2PLD1HDAC1HDAC2HTR7 | |
| SCHEMBL21268795 | 0.80 | HTR7 (0.71) | CNR2PLD1HDAC1HDAC2HTR7 | |
| SCHEMBL1743234 | 0.79 | CNR2 (0.68) | CNR2HTR1AACVR1BTGFBR1MAPT | |
| SCHEMBL1743039 | 0.79 | CNR2 (0.68) | CNR2ACVR1BTGFBR1MAPTACVR1 | |
| SCHEMBL893565 | 0.79 | PLD1 (1.00) | PLD1HTR7HTR1ABPTFMEN1 | |
| SCHEMBL7900 | 0.79 | PLD1 (1.00) | PLD1HTR7HTR1ABPTFMEN1 | |
| SCHEMBL29400889 | 0.79 | PLD1 (1.00) | PLD1HTR7HTR1ABPTFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807085-B1 | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors | XENON PHARMACEUTICALS INC (CA) | 2013-08-21 | — | — | EP | disclosed |
| EP-2266569-A2 | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors | Xenon Pharmaceuticals Inc. (CA) | 2010-12-29 | — | — | EP | disclosed |
| US-7767677-B2 | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors | XENON PHARMACEUTICALS INC. (CA) | 2010-08-03 | — | — | US | disclosed |
| US-20080096895-A1 | Heterocyclic Derivatives and Their Use as Stearoyl-Coa Desaturase Inhibitors | XENON PHARMACEUTICALS INC. (CA) | 2008-04-24 | — | — | US | disclosed |
| EP-1807085-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006034440-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096895-A1 | Heterocyclic Derivatives and Their Use as Stearoyl-Coa Desaturase Inhibitors | SCD, SCD5, ECHS1 | CNR2 553/4885PLD1 1042/4885HDAC1 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.