Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylamine SCHEMBL2760772 | 0.88 | TSHR (0.42) | TSHR | |
| Hydrochloric Acid SCHEMBL28899614 | 0.83 | TSHR (0.47) | TSHR | |
| Hydrochloric Acid SCHEMBL28899726 | 0.83 | TSHR (0.47) | TSHR | |
| Hydrochloric Acid SCHEMBL28899670 | 0.83 | TSHR (0.47) | TSHR | |
| Hydrochloric Acid SCHEMBL28899621 | 0.83 | TSHR (0.47) | TSHR | |
| Hydrochloric Acid SCHEMBL29163705 | 0.83 | TSHR (0.47) | TSHR | |
| SCHEMBL4602343 | 0.81 | TSHR (0.44) | KMT2ATSHR | |
| Bromide SCHEMBL27620439 | 0.79 | DNM1 (0.45) | ALDH1A1ALOX15TSHR | |
| Hydrochloric Acid SCHEMBL8682761 | 0.74 | TSHR (0.35) | THRBTSHRTDP1 | |
| SCHEMBL12522537 | 0.71 | MEN1 (0.36) | MEN1LMNAKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842286-B2 | Dimethicone copolymer cross linked with C3 to C20 alkyl groups; first alkoxylated compound is polyethylenoxides with a molecular weight 500 to 700 and other alkoxylated compound is fatty acid esters of bis-(polyethylenoxide)polydimethylsiloxane; ethoxylated hydrogenated castor oil; a fat; water phase | THE PROCTER & GAMBLE COMPANY (US) | 2010-11-30 | — | — | US | disclosed |
| EP-1726331-B1 | Moisture resistant hair styling composition containing two copolymers | WELLA AG (DE) | 2008-11-12 | — | — | EP | disclosed |
| EP-1745769-B1 | Hair treatment method using dry foam as mechanical support for hair | WELLA AG (DE) | 2008-10-15 | — | — | EP | disclosed |
| US-20080089855-A1 | Non-fluid hair treatment product comprising hair fixative absorbed on waxy carrier | THE PROCTER & GAMBLE COMPANY | 2008-04-17 | — | — | US | disclosed |
| WO-2008041202-A1 | NON-FLUID HAIR TREATMENT PRODUCT COMPRISING HAIR FIXATIVE ABSORBED ON WAXY CARRIER | THE PROCTER & GAMBLE COMPANY (US) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908456-A1 | Non-fluid hair treatment product comprising hair fixative absorbed on waxy carrier | Wella Aktiengesellschaft (DE) | 2008-04-09 | — | — | EP | disclosed |
| US-20070202068-A1 | Dimethicone copolymer cross linked with C3 to C20 alkyl groups; first alkoxylated compound is polyethylenoxides with a molecular weight 500 to 700 and other alkoxylated compound is fatty acid esters of bis-(polyethylenoxide)polydimethylsiloxane; ethoxylated hydrogenated castor oil; a fat; water phase | PROCTER & GAMBLE COMPANY, THE | 2007-08-30 | — | — | US | disclosed |
| US-20070197704-A1 | Moisture resistant hair styling composition containing two copolymers | THE PROCTER & GAMBLE COMPANY (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070148102-A1 | Hair treament method using dry foam as mechanical support for hair | PROCTER & GAMBLE COMPANY, THE | 2007-06-28 | — | — | US | disclosed |
| WO-2007063520-A2 | HAIR STYLING CREAM | THE PROCTER & GAMBLE COMPANY (US) | 2007-06-07 | — | — | WO | disclosed |
| EP-1792640-A1 | Hair styling cream | Wella Aktiengesellschaft (DE) | 2007-06-06 | — | — | EP | disclosed |
| WO-2007010494-A1 | HAIR TREATMENT METHOD USING DRY FOAM AS MECHANICAL SUPPORT FOR HAIR | THE PROCTER & GAMBLE COMPANY (US) | 2007-01-25 | — | — | WO | disclosed |
| EP-1745769-A1 | Hair treatment method using dry foam as mechanical support for hair | Wella Aktiengesellschaft (DE) | 2007-01-24 | — | — | EP | disclosed |
| WO-2006130372-A1 | MOISTURE RESISTANT HAIR STYLING COMPOSITION CONTAINING TWO COPOLYMERS | THE PROCTER & GAMBLE COMPANY (US) | 2006-12-07 | — | — | WO | disclosed |
| EP-1726331-A1 | Moisture resistant hair styling composition containing two copolymers | Wella Aktiengesellschaft (DE) | 2006-11-29 | — | — | EP | disclosed |