Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Propylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 10/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29163705 | 0.93 | TSHR (0.47) | TSHRDNM1HTTENPP2PLA2G1B | |
| Hydrochloric Acid SCHEMBL28899670 | 0.93 | TSHR (0.47) | TSHRDNM1HTTENPP2PLA2G1B | |
| Hydrochloric Acid SCHEMBL28899621 | 0.93 | TSHR (0.47) | TSHRDNM1HTTENPP2PLA2G1B | |
| Hydrochloric Acid SCHEMBL28899726 | 0.93 | TSHR (0.47) | TSHRDNM1HTTENPP2PLA2G1B | |
| Hydrochloric Acid SCHEMBL28899614 | 0.93 | TSHR (0.47) | TSHRDNM1HTTENPP2PLA2G1B | |
| SCHEMBL4602343 | 0.91 | TSHR (0.44) | TSHRDNM1HTT | |
| Bromide SCHEMBL27620439 | 0.90 | DNM1 (0.45) | TSHRDNM1HTTHSP90AA1RAD52 | |
| Hydrochloric Acid SCHEMBL2760773 | 0.88 | PAOX (0.41) | TSHR | |
| Hydrochloric Acid SCHEMBL8682761 | 0.78 | TSHR (0.35) | TSHR | |
| SCHEMBL17036766 | 0.76 | BBOX1 (0.34) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842286-B2 | Dimethicone copolymer cross linked with C3 to C20 alkyl groups; first alkoxylated compound is polyethylenoxides with a molecular weight 500 to 700 and other alkoxylated compound is fatty acid esters of bis-(polyethylenoxide)polydimethylsiloxane; ethoxylated hydrogenated castor oil; a fat; water phase | THE PROCTER & GAMBLE COMPANY (US) | 2010-11-30 | — | — | US | disclosed |
| EP-1726331-B1 | Moisture resistant hair styling composition containing two copolymers | WELLA AG (DE) | 2008-11-12 | — | — | EP | disclosed |
| EP-1745769-B1 | Hair treatment method using dry foam as mechanical support for hair | WELLA AG (DE) | 2008-10-15 | — | — | EP | disclosed |
| US-20080089855-A1 | Non-fluid hair treatment product comprising hair fixative absorbed on waxy carrier | THE PROCTER & GAMBLE COMPANY | 2008-04-17 | — | — | US | disclosed |
| WO-2008041202-A1 | NON-FLUID HAIR TREATMENT PRODUCT COMPRISING HAIR FIXATIVE ABSORBED ON WAXY CARRIER | THE PROCTER & GAMBLE COMPANY (US) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908456-A1 | Non-fluid hair treatment product comprising hair fixative absorbed on waxy carrier | Wella Aktiengesellschaft (DE) | 2008-04-09 | — | — | EP | disclosed |
| US-20070202068-A1 | Dimethicone copolymer cross linked with C3 to C20 alkyl groups; first alkoxylated compound is polyethylenoxides with a molecular weight 500 to 700 and other alkoxylated compound is fatty acid esters of bis-(polyethylenoxide)polydimethylsiloxane; ethoxylated hydrogenated castor oil; a fat; water phase | PROCTER & GAMBLE COMPANY, THE | 2007-08-30 | — | — | US | disclosed |
| US-20070197704-A1 | Moisture resistant hair styling composition containing two copolymers | THE PROCTER & GAMBLE COMPANY (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070148102-A1 | Hair treament method using dry foam as mechanical support for hair | PROCTER & GAMBLE COMPANY, THE | 2007-06-28 | — | — | US | disclosed |
| WO-2007063520-A2 | HAIR STYLING CREAM | THE PROCTER & GAMBLE COMPANY (US) | 2007-06-07 | — | — | WO | disclosed |
| EP-1792640-A1 | Hair styling cream | Wella Aktiengesellschaft (DE) | 2007-06-06 | — | — | EP | disclosed |
| WO-2007010494-A1 | HAIR TREATMENT METHOD USING DRY FOAM AS MECHANICAL SUPPORT FOR HAIR | THE PROCTER & GAMBLE COMPANY (US) | 2007-01-25 | — | — | WO | disclosed |
| EP-1745769-A1 | Hair treatment method using dry foam as mechanical support for hair | Wella Aktiengesellschaft (DE) | 2007-01-24 | — | — | EP | disclosed |
| WO-2006130372-A1 | MOISTURE RESISTANT HAIR STYLING COMPOSITION CONTAINING TWO COPOLYMERS | THE PROCTER & GAMBLE COMPANY (US) | 2006-12-07 | — | — | WO | disclosed |
| EP-1726331-A1 | Moisture resistant hair styling composition containing two copolymers | Wella Aktiengesellschaft (DE) | 2006-11-29 | — | — | EP | disclosed |