Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | COMT | P21964 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2274802 | 0.80 | KDM4E (0.49) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL27610216 | 0.76 | PIK3CD (0.44) | KDM4ENPC1LMNATP53ALOX15 | |
| SCHEMBL8055697 | 0.75 | ACHE (0.55) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL16597048 | 0.73 | PIK3CD (0.52) | TSHRKDM4EL3MBTL1NPC1LMNA | |
| SCHEMBL6051223 | 0.73 | KDM4E (0.57) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL10877426 | 0.73 | METAP2 (0.66) | TSHRMMP2CHRM1COMTADRA1A | |
| Dipyridyl SCHEMBL9615229 | 0.73 | TSHR (0.78) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL1119653 | 0.72 | NQO2 (0.50) | TSHRMMP2CHRM1COMTADRA1A | |
| Carbon Monoxide SCHEMBL6349236 | 0.72 | KDM4E (0.49) | TSHRMETAP2METAP1KDM4EL3MBTL1 | |
| SCHEMBL3234119 | 0.71 | TSHR (0.49) | TSHRMMP2CHRM1COMTADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1681791-B | 8-hydroxy quinoline derivatives | PRANA BIOTECHNOLOGY LTD | 2013-03-27 | — | — | CN | disclosed |
| CN-1681791-A | 8-hydroxy quinoline derivatives | PRANA BIOTECHNOLOGY LTD (AU) | 2005-10-12 | — | — | CN | disclosed |