Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2761178 | 0.90 | TSHR (0.48) | TSHRALDH1A1HTTCCR5HRH3 | |
| SCHEMBL2761194 | 0.87 | MAPT (0.34) | ALDH1A1HTTHRH3NPSR1SMN1; SMN2 | |
| SCHEMBL2761282 | 0.85 | LMNA (0.42) | ALDH1A1HTTHRH3NPSR1POLB | |
| SCHEMBL5226495 | 0.79 | NPSR1 (0.44) | TSHRALDH1A1HTTHRH3MEN1 | |
| SCHEMBL2761138 | 0.76 | LMNA (0.40) | HTTNPSR1POLBLMNA | |
| SCHEMBL2761010 | 0.76 | MAPT (0.41) | HTTHRH3NPSR1POLBLMNA | |
| SCHEMBL2761238 | 0.74 | LMNA (0.51) | ALDH1A1HRH3MEN1KMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL1997591 | 0.73 | LMNA (0.50) | ALDH1A1HTTHRH3MEN1KMT2A | |
| SCHEMBL1994787 | 0.73 | MAPT (0.33) | ALDH1A1HTTHRH3NPSR1SMN1; SMN2 | |
| SCHEMBL1998682 | 0.72 | MAPT (0.35) | HTTHRH3NPSR1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842695-B2 | Substituted pyrazole compounds | MERCK PATENT GMBH (DE) | 2010-11-30 | — | — | US | disclosed |
| US-20070010531-A1 | Substituted pyrazole compounds | MERCK PATENT GMBH (DE) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010531-A1 | Substituted pyrazole compounds | HTR3A, HTR1A, HTR1D | TSHR 134/4885ALDH1A1 897/4885HTT 1197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.