Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29102668 | 0.84 | LMNA (0.50) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL1664496 | 0.83 | LMNA (0.44) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL27840672 | 0.81 | LMNA (0.47) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL15327919 | 0.80 | SMN1; SMN2 (0.54) | KDM4EALDH1A1MAPTADRA1DPARP1 | |
| SCHEMBL11022537 | 0.80 | LMNA (0.46) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL4027334 | 0.80 | LMNA (0.46) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL6823635 | 0.80 | LMNA (0.46) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL4427821 | 0.79 | LMNA (0.53) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL27914648 | 0.79 | ALDH1A1 (0.38) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL21812525 | 0.78 | PARP1 (0.44) | LMNAMAP3K14KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1688573-A | Pyrrole based inhibitors of glycogen synthase kinase 3 | CHIRON CORP (US) | 2005-10-26 | — | — | CN | disclosed |