Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27611348 | 0.80 | LMNA (0.53) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL29102668 | 0.77 | LMNA (0.50) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL27840672 | 0.74 | LMNA (0.47) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL11022537 | 0.72 | LMNA (0.46) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL6823635 | 0.72 | LMNA (0.46) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL4427821 | 0.72 | LMNA (0.53) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL29038553 | 0.71 | ICMT (0.48) | LMNAMAP3K14KDM4EMEN1MAPT | |
| SCHEMBL28137548 | 0.71 | ICMT (0.48) | LMNAMAP3K14KDM4EMEN1MAPT | |
| SCHEMBL27817843 | 0.70 | KDM4E (0.46) | LMNAMAP3K14KDM4EALDH1A1MEN1 | |
| SCHEMBL7489244 | 0.70 | TP53 (0.37) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261601-B1 | SUBSTITUTED INDOLES FOR MODULATING NFKB ACTIVITY | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-29 | — | — | EP | disclosed |