Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28542523 | 0.87 | KDM4E (0.41) | KDM4ECYP1A2MAPTGAANPSR1 | |
| SCHEMBL29394811 | 0.83 | PAX8 (0.43) | KDM4ECYP1A2MAPTL3MBTL1HTT | |
| SCHEMBL4668812 | 0.81 | L3MBTL1 (0.57) | KDM4ECYP1A2MAPTGAANPSR1 | |
| SCHEMBL1515657 | 0.81 | KDM4E (0.44) | KDM4ECYP1A2MAPTGAANPSR1 | |
| SCHEMBL25243173 | 0.79 | MAPT (0.42) | KDM4ECYP1A2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL2334108 | 0.79 | ALDH1A1 (0.38) | KDM4ECYP1A2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL2178576 | 0.79 | SMN1; SMN2 (0.47) | KDM4ECYP1A2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL31439135 | 0.79 | PARP1 (0.51) | KDM4EMAPTNPSR1ALDH1A1L3MBTL1 | |
| SCHEMBL999250 | 0.79 | P2RX7 (0.50) | KDM4ECYP1A2MAPTALDH1A1PARP1 | |
| SCHEMBL6513742 | 0.79 | PLAU (0.44) | MAPTL3MBTL1HTTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |