Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27612476 | 0.83 | SYK (0.43) | RAB9APOLBMAPTNPC1TDP1 | |
| SCHEMBL27612546 | 0.80 | SYK (0.50) | POLBMAPTLMNAALDH1A1KMT2A | |
| SCHEMBL4802215 | 0.76 | DHFR (0.48) | HPGDMAPTLMNAALDH1A1TDP1 | |
| SCHEMBL27631612 | 0.76 | FKBP1A (0.51) | RAB9AHPGDPOLBMAPTLMNA | |
| SCHEMBL1950061 | 0.74 | ALDH1A1 (0.68) | RAB9AHPGDPOLBMAPTLMNA | |
| SCHEMBL4805497 | 0.72 | KMT2A (0.46) | MAPTLMNAALDH1A1KMT2A | |
| SCHEMBL27612500 | 0.72 | SYK (0.45) | POLB | |
| SCHEMBL27631855 | 0.72 | DHFR (0.40) | LMNASMN1; SMN2 | |
| Bicarbonate SCHEMBL3847311 | 0.71 | ALDH1A1 (0.62) | RAB9AHPGDPOLBMAPTLMNA | |
| Bicarbonate SCHEMBL3847310 | 0.71 | ALDH1A1 (0.62) | RAB9AHPGDPOLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |