Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4805497 | 0.87 | KMT2A (0.46) | DHFRSYKLMNATSHRABCB1 | |
| SCHEMBL27631855 | 0.87 | DHFR (0.40) | DHFRSYKSMN1; SMN2LMNAPKM | |
| SCHEMBL27612500 | 0.84 | SYK (0.45) | DHFRSYKABCB1TUBB3PKM | |
| SCHEMBL27612476 | 0.83 | SYK (0.43) | SYKTDP1MAPTMEN1KMT2A | |
| SCHEMBL27612546 | 0.82 | SYK (0.50) | SYKSMN1; SMN2LMNATSHRMAPT | |
| SCHEMBL4802208 | 0.79 | SYK (0.44) | DHFRSYKMAPTKDM4EMEN1 | |
| SCHEMBL4801168 | 0.79 | SYK (0.54) | SYKSMN1; SMN2LMNATDP1TSHR | |
| SCHEMBL27612594 | 0.78 | MAPT (0.49) | DHFRSMN1; SMN2LMNATDP1TSHR | |
| SCHEMBL27612831 | 0.76 | RAB9A (0.47) | SMN1; SMN2LMNATDP1MAPTHPGD | |
| SCHEMBL4798557 | 0.75 | SYK (0.48) | DHFRSYKMAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329672-B2 | 2,4-pyrimidinediamine compounds and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-12 | — | — | US | disclosed |