Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 1/20 | 0.74 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.68 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | SRC | P12931 | 2/20 | 0.68 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.68 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.68 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.68 |
| ▸ | LDHA | P00338 | 1/20 | 0.68 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.68 |
| ▸ | FBP1 | P09467 | 1/20 | 0.68 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.68 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.68 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.68 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8846496 | 0.93 | MARS1 (0.73) | MARS1P2RY1ADORA1P2RY2SMN1; SMN2 | |
| SCHEMBL7757016 | 0.91 | MARS1 (0.73) | MARS1P2RY1ADORA1P2RY2SMN1; SMN2 | |
| SCHEMBL11684787 | 0.90 | MARS1 (0.62) | MARS1P2RY1ADORA1P2RY2SMN1; SMN2 | |
| SCHEMBL11584743 | 0.90 | P2RY1 (0.71) | MARS1P2RY1ADORA1P2RY2SMN1; SMN2 | |
| SCHEMBL5550634 | 0.90 | P2RY1 (0.71) | MARS1P2RY1ADORA1P2RY2SMN1; SMN2 | |
| SCHEMBL31001632 | 0.90 | P2RY1 (0.71) | MARS1P2RY1ADORA1P2RY2SMN1; SMN2 | |
| SCHEMBL219554 | 0.90 | P2RY1 (0.71) | MARS1P2RY1ADORA1P2RY2SMN1; SMN2 | |
| SCHEMBL11585557 | 0.89 | MARS1 (0.68) | MARS1P2RY1ADORA1P2RY2SMN1; SMN2 | |
| SCHEMBL16256555 | 0.89 | MARS1 (0.61) | MARS1P2RY1ADORA1P2RY2SMN1; SMN2 | |
| SCHEMBL2463542 | 0.89 | PRKACA (0.73) | MARS1P2RY1ADORA1P2RY2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2261334-B1 | Modified polynucleotides for use in RNA interference | THERMO FISHER SCIENT BIOSCIENCES INC (US) | 2014-02-26 | — | — | EP | disclosed |
| EP-1733035-B1 | MODIFIED POLYNUCLEOTIDES FOR REDUCING OFF-TARGET EFFECTS IN RNA INTERFERENCE | DHARMACON INC (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012023152-A3 | MULTI-PROCESSOR ELECTRONIC SYSTEMS | INEDA SYSTEMS PVT. LTD (IN) | 2012-05-10 | — | — | WO | disclosed |
| EP-1608733-B1 | MODIFIED POLYNUCLEOTIDES FOR USE IN RNA INTERFERENCE | DHARMACON INC (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-2261334-A2 | Modified polynucleotides for use in RNA interference | Dharmacon, Inc. (US) | 2010-12-15 | — | — | EP | disclosed |
| US-20100197023-A1 | MODIFIED POLYNUCLEOTIDES FOR USE IN RNA INTERFERENCE | DHARMACON INC. (US) | 2010-08-05 | — | — | US | disclosed |
| EP-2123759-A2 | Stabilized RNAS as transfection controls and silencing reagents | Dharmacon, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20090280567-A1 | STABILIZED SIRNAS AS TRANSFECTION CONTROLS AND SILENCING REAGENTS | DHARMACON, INC. (US) | 2009-11-12 | — | — | US | disclosed |
| EP-1718747-B1 | STABILIZED RNAS AS TRANSFECTION CONTROLS AND SILENCING REAGENTS | DHARMACON INC (US) | 2009-10-28 | — | — | EP | disclosed |
| US-7595387-B2 | Modified polynucleotides for reducing off-target effects in RNA interference | DHARMACON, INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-20070167384-A1 | Modified polynucleotides for use in rna interference | DHARMACON, INC. (US) | 2007-07-19 | — | — | US | disclosed |
| EP-1733035-A2 | MODIFIED POLYNUCLEOTIDES FOR REDUCING OFF-TARGET EFFECTS IN RNA INTERFERENCE | Dharmacon, Inc. (US) | 2006-12-20 | — | — | EP | disclosed |
| EP-1718747-A2 | STABILIZED RNAS AS TRANSFECTION CONTROLS AND SILENCING REAGENTS | Dharmacon, Inc. (US) | 2006-11-08 | — | — | EP | disclosed |
| EP-1608733-A2 | MODIFIED POLYNUCLEOTIDES FOR USE IN RNA INTERFERENCE | Dharmacon, Inc. (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2005097992-A2 | MODIFIED POLYNUCLEOTIDES FOR REDUCING OFF-TARGET EFFECTS IN RNA INTERFERENCE | DHARMACON, INC. (US) | 2005-10-20 | — | — | WO | disclosed |
| WO-2005078094-A2 | STABILIZED RNAS AS TRANSFECTION CONTROLS AND SILENCING REAGENTS | DHARMACON, INC. (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005078095-A1 | SNP DISCRIMINATORY siRNA | DHARMACON, INC. (US) | 2005-08-25 | — | — | WO | disclosed |
| US-20050176045-A1 | SNP discriminatory siRNA | DHARMACON, INC. (US) | 2005-08-11 | — | — | US | disclosed |
| WO-2004090105-A2 | MODIFIED POLYNUCLEOTIDES FOR USE IN RNA INTERFERENCE | DHARMACON, INC. (US) | 2004-10-21 | — | — | WO | disclosed |
| EP-0175325-A2 | New 8-substituted nucleoside and purine derivatives, the process for the preparation thereof and the pharmaceutical compositions containing them | Pierrel S.p.A. (IT) | 1986-03-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090280567-A1 | STABILIZED SIRNAS AS TRANSFECTION CONTROLS AND SILENCING REAGENTS | PHAX, NSUN2, UPF1 | MARS1 317/4885P2RY1 1096/4885ADORA1 1122/4885 |
| US-20070167384-A1 | Modified polynucleotides for use in rna interference | PHAX, NSUN2, RNMT | MARS1 322/4885P2RY1 2298/4885ADORA1 2130/4885 |
| US-20100197023-A1 | MODIFIED POLYNUCLEOTIDES FOR USE IN RNA INTERFERENCE | PHAX, NSUN2, RNMT | MARS1 322/4885P2RY1 2298/4885ADORA1 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.