Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.63 |
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2216123 | 0.83 | NPC1 (0.67) | MKNK1MKNK2CYP3A4CYP2A6ALDH1A1 | |
| SCHEMBL1348239 | 0.83 | MKNK1 (0.56) | MKNK1MKNK2CYP3A4CYP2A6ALDH1A1 | |
| SCHEMBL4630925 | 0.80 | KIF11 (0.62) | CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29786195 | 0.80 | KMT2A (0.55) | MKNK1MKNK2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL283911 | 0.80 | KMT2A (0.55) | MKNK1MKNK2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL1955422 | 0.80 | KIF11 (0.61) | CYP1A2CA1CA2CA9CYP2C9 | |
| SCHEMBL4645134 | 0.80 | MKNK1 (0.58) | MKNK1MKNK2CYP3A4CYP2A6ALDH1A1 | |
| SCHEMBL21312877 | 0.79 | MKNK1 (0.50) | MKNK1MKNK2CYP3A4CA12CA1 | |
| SCHEMBL30855339 | 0.77 | MKNK1 (1.00) | MKNK1MKNK2CYP3A4CYP2A6ALDH1A1 | |
| SCHEMBL606654 | 0.77 | MKNK1 (1.00) | MKNK1MKNK2CYP3A4CYP2A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102869658-B | modulators of fatty acid amide hydrolase | JANSSEN PHARMACEUTICA N.V. (BE) | 2015-09-02 | — | — | CN | disclosed |
| CN-101595102-B | Diaryl ether urea compounds | PFIZER PROD INC | 2013-08-07 | — | — | CN | disclosed |
| CN-101146786-B | Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase | JANSSEN PHARMACEUTICA NV | 2013-03-27 | — | — | CN | disclosed |
| CN-102869658-A | Modulators of fatty acid amide hydrolase | JANSSEN PHARMACEUTICA NV | 2013-01-09 | — | — | CN | disclosed |
| CN-101595102-A | Diaryl ether urea compounds | PFIZER PROD INC (US) | 2009-12-02 | — | — | CN | disclosed |
| CN-101426791-A | Purine derivatives having activity at the adenosine A2A receptor | NOVARTIS AG (CH) | 2009-05-06 | — | — | CN | disclosed |
| CN-101146786-A | Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase | JANSSEN PHARMACEUTICA NV (BE) | 2008-03-19 | — | — | CN | disclosed |
| CN-1638761-A | Azetidine derivatives as CCR-3 receptor antagonists | NOVARTIS AG (CH) | 2005-07-13 | — | — | CN | disclosed |