Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.51 |
| ▸ | ACACA | Q13085 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15785422 | 0.86 | CYP3A4 (0.59) | MKNK1MKNK2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL1814097 | 0.82 | MAPT (0.52) | MAPTRAB9AALDH1A1GLA | |
| SCHEMBL30588953 | 0.82 | MAPT (0.52) | MAPTRAB9AALDH1A1GLA | |
| SCHEMBL5057157 | 0.82 | ACACA (0.61) | ACACAMAPTRAB9AALDH1A1 | |
| SCHEMBL27615591 | 0.80 | MKNK1 (0.63) | MKNK1MKNK2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL16197899 | 0.78 | NOTUM (0.70) | MKNK1MKNK2CYP3A4CYP2D6RAB9A | |
| SCHEMBL5751218 | 0.78 | CYP19A1 (0.73) | MKNK1MKNK2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL13492969 | 0.76 | MKNK1 (0.63) | MKNK1MKNK2CYP3A4CYP2A6ALDH1A1 | |
| SCHEMBL14080906 | 0.76 | CYP19A1 (0.71) | MKNK1MKNK2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL19599648 | 0.76 | CYP2C9 (0.62) | MKNK1MKNK2CYP3A4CYP2D6CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663204-A4 | C-KIT MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1663204-A2 | C-KIT MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005020921-A2 | C-KIT MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-03-10 | — | — | WO | disclosed |