Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1348104 | 0.84 | KMO (0.54) | MKNK1MKNK2CYP19A1CYP3A4CYP2A6 | |
| SCHEMBL27615591 | 0.83 | MKNK1 (0.63) | MKNK1MKNK2CYP19A1CYP3A4CYP2A6 | |
| SCHEMBL2216123 | 0.83 | NPC1 (0.67) | MKNK1MKNK2CYP19A1CYP3A4CYP2A6 | |
| SCHEMBL1532656 | 0.80 | KMT2A (0.58) | ALDH1A1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL1347723 | 0.80 | KMT2A (0.53) | CYP1A2CYP2C9CYP2C19NPC1RAB9A | |
| SCHEMBL6565732 | 0.80 | HSD17B10 (0.47) | ALDH1A1CYP1A2CYP2C9CYP2C19NPC1 | |
| Hydrochloric Acid SCHEMBL10604528 | 0.79 | KMT2A (0.61) | ALDH1A1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL206263 | 0.77 | MKNK1 (0.71) | MKNK1MKNK2CYP19A1CYP3A4CYP2A6 | |
| Benzene SCHEMBL28562974 | 0.75 | MKNK1 (0.50) | MKNK1MKNK2CYP19A1CYP3A4CYP2A6 | |
| SCHEMBL24534338 | 0.75 | CYP2A6 (0.88) | MKNK1MKNK2CYP19A1CYP3A4CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063021-B2 | Ketolide anti-infective compounds | KOSAN BIOSCIENCES INCORPORATED (US) | 2011-11-22 | — | — | US | disclosed |
| US-20050272672-A1 | Ketolide anti-infective compounds | KOSAN BIOSCIENCES, INC. (US) | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272672-A1 | Ketolide anti-infective compounds | HK1, AKR1D1, KHK | MKNK1 1526/4885MKNK2 2441/4885CYP19A1 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.