Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27597023 | 0.81 | ATM (0.43) | ATMCYP2C9TSHRCYP1A2ADRA2A | |
| SCHEMBL27645340 | 0.80 | ATM (0.42) | ATMCYP2C9TSHRCYP1A2ADRA2A | |
| SCHEMBL3173494 | 0.67 | ATM (0.40) | ATM | |
| SCHEMBL653703 | 0.65 | RAB9A (0.50) | TSHRMAOARAB9ANPC1MAPT | |
| SCHEMBL11862871 | 0.64 | SRD5A2 (0.48) | TSHRCYP1A2ALDH1A1HPGDKDM4E | |
| SCHEMBL20607653 | 0.63 | MEN1 (0.44) | CYP2C9TSHRPPARGALDH1A1HPGD | |
| SCHEMBL15846800 | 0.61 | SRD5A2 (0.58) | ATMCYP1A2ALDH1A1HPGDLMNA | |
| SCHEMBL27666446 | 0.60 | LMNA (0.36) | ATMTSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL11858223 | 0.59 | GPR35 (0.67) | TSHRMAPTHSD17B10KCNK3KCNK9 | |
| SCHEMBL28652104 | 0.59 | HPGD (0.45) | ATMTSHRCYP1A2ADRA2AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100358891-C | Pyranones useful as ATM inhibitors | KUDOS PHARM LTD (GB) | 2008-01-02 | — | — | CN | disclosed |
| CN-1639154-A | Pyranones useful as ATM inhibitors | KUDOS PHARM LTD (GB) | 2005-07-13 | — | — | CN | disclosed |