Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27597023 | 0.86 | ATM (0.43) | ATMCYP1A2ADRA2AMAOASLC6A2 | |
| SCHEMBL3173494 | 0.83 | ATM (0.40) | ATMCA12CA1CA9 | |
| SCHEMBL27615683 | 0.80 | ATM (0.39) | ATMCYP1A2ADRA2AMAOASLC6A2 | |
| SCHEMBL5773768 | 0.79 | ATM (0.39) | ATMCYP1A2ADRA2AMAOASLC6A2 | |
| SCHEMBL27666446 | 0.77 | LMNA (0.36) | ATMRAB9ANPC1SMN1; SMN2PIK3CA | |
| SCHEMBL3159752 | 0.74 | BLM (0.46) | ATMRAB9ANPC1SMN1; SMN2PRKDC | |
| SCHEMBL17820794 | 0.72 | RAB9A (0.39) | CYP1A2ADRA2AMAOASLC6A2HTR2C | |
| SCHEMBL17820115 | 0.69 | RAB9A (0.39) | CYP1A2ADRA2AMAOASLC6A2HTR2C | |
| SCHEMBL17820007 | 0.67 | TRPM8 (0.40) | RAB9ANPC1SMN1; SMN2CA12CA9 | |
| SCHEMBL5545887 | 0.65 | ALDH1A1 (0.34) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1867566-B | Aminopyranones and their use as ATM inhibitors | KUDOS PHARM LTD | 2010-06-16 | — | — | CN | disclosed |
| CN-1867566-A | Aminopyranones and their use as ATM inhibitors | KUDOS PHARM LTD (GB) | 2006-11-22 | — | — | CN | disclosed |