Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.35 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL49123 | 0.81 | L3MBTL1 (0.47) | PIK3CDPIK3CGPI4KBPIK3CAPIK3C3 | |
| SCHEMBL27615727 | 0.81 | PIK3CD (0.46) | PIK3CDPIK3CGPI4KBPIK3CAPIK3C3 | |
| Bromide SCHEMBL48510 | 0.80 | L3MBTL1 (0.46) | PIK3CDPIK3CGPI4KBPIK3CAPIK3C3 | |
| SCHEMBL28761626 | 0.75 | MAPK1 (0.31) | — | |
| SCHEMBL48627 | 0.74 | PIK3CD (0.51) | PIK3CDPIK3CGPI4KBPIK3CAPIK3C3 | |
| SCHEMBL27615777 | 0.68 | PIK3CG (0.46) | PIK3CDPIK3CGPI4KBPIK3CAPIK3C3 | |
| SCHEMBL1786529 | 0.67 | PIK3CD (0.63) | PIK3CDPIK3CGPI4KBPIK3CAPIK3C3 | |
| SCHEMBL27667448 | 0.67 | ADORA3 (0.36) | KDM4EHRH4 | |
| SCHEMBL27699537 | 0.66 | KMT2A (0.38) | KDM4E | |
| SCHEMBL27593641 | 0.64 | ALDH1A1 (0.39) | KDM4EHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100548996-C | 5-phenylthiazole derivatives and their use for the preparation of medicaments | NOVARTIS AG (CH) | 2009-10-14 | — | — | CN | disclosed |
| CN-1639139-A | 5-phenylthiazole derivatives and use as PI3 kinase inhibitors | NOVARTIS AG (CH) | 2005-07-13 | — | — | CN | disclosed |