Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | LIFR | P42702 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5557504 | 0.89 | AAK1 (0.37) | RAB9AALDH1A1NPC1SMN1; SMN2MAPT | |
| SCHEMBL27615901 | 0.87 | RAB9A (0.41) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL27597124 | 0.86 | POLB (0.41) | RAB9AALDH1A1MEN1KMT2AABL1 | |
| SCHEMBL27615862 | 0.84 | RAB9A (0.39) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL27597107 | 0.83 | MEN1 (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL27615869 | 0.82 | WNT3A (0.44) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL27615835 | 0.82 | WNT3A (0.44) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL27597164 | 0.81 | ALDH1A1 (0.45) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL27597134 | 0.79 | RAB9A (0.42) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL27615899 | 0.79 | RAB9A (0.42) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497333-C | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2009-06-10 | — | — | CN | disclosed |
| CN-1633430-A | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2005-06-29 | — | — | CN | disclosed |