Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 2/20 | 0.36 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5562825 | 0.89 | POLB (0.35) | DRD4POLBMAPTLMNADRD2 | |
| SCHEMBL28754186 | 0.87 | POLB (0.40) | RAB9APOLBWNT3APTGESIDO1 | |
| SCHEMBL27615901 | 0.85 | RAB9A (0.41) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL27615907 | 0.84 | RAB9A (0.40) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL27615925 | 0.83 | POLB (0.39) | POLBWNT3APTGESIDO1 | |
| SCHEMBL27615982 | 0.82 | MEN1 (0.46) | ALDH1A1MEN1KMT2APOLBIDO1 | |
| SCHEMBL27615869 | 0.81 | WNT3A (0.44) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL27615835 | 0.81 | WNT3A (0.44) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL27597134 | 0.79 | RAB9A (0.42) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL27597164 | 0.79 | ALDH1A1 (0.45) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497333-C | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2009-06-10 | — | — | CN | disclosed |
| CN-1633430-A | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2005-06-29 | — | — | CN | disclosed |