Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | BAD | Q92934 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28793830 | 0.77 | CES2 (0.46) | HTR7CES2CES1BCL2L1BAD | |
| SCHEMBL4884033 | 0.77 | HTR7 (0.47) | HTR7CES2CES1BCL2L1BAD | |
| SCHEMBL1456797 | 0.76 | ATM (0.54) | CES2CES1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL8017500 | 0.75 | HTR7 (0.45) | HTR7CES2CES1PTPN1NPC1 | |
| SCHEMBL16953649 | 0.75 | CES2 (0.44) | CES2CES1CA1 | |
| SCHEMBL16961038 | 0.75 | CES2 (0.50) | CES2CES1RAB9ALMNAALDH1A1 | |
| SCHEMBL6981701 | 0.75 | ATM (0.43) | HTR7CES2CES1NPC1RAB9A | |
| Alcohol SCHEMBL28041790 | 0.74 | ACHE (0.53) | HTR7CES2CES1PTPN1CA1 | |
| SCHEMBL655375 | 0.73 | HTR7 (0.64) | HTR7CES2CES1BCL2L1BAD | |
| SCHEMBL20622547 | 0.73 | HTR7 (0.44) | HTR7CES2CES1PTPN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100467448-C | Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use | AVENTIS PHARMA GMBH (DE) | 2009-03-11 | — | — | CN | disclosed |
| CN-1662495-A | Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use | AVENTIS PHARMA GMBH (DE) | 2005-08-31 | — | — | CN | disclosed |