SCHEMBL2761891

SCHEMBL2761891

c1c2c(cc3c1COC3)COC2

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PRKCG P05129 1/20 0.43
PRKCA P17252 1/20 0.43
PRKCD Q05655 1/20 0.43
KDM4E B2RXH2 1/20 0.35
MAPT P10636 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
PTGS2 P35354 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12611103 0.85 PRKCG (0.40) PRKCGPRKCAPRKCDKDM4EMAPT
SCHEMBL17864275 0.79 PTK2 (0.41) PRKCGPRKCAPRKCDKDM4EMAPT
SCHEMBL13822493 0.78 GRIN2D (0.33) PRKCGPRKCAPRKCD
SCHEMBL3221430 0.75 MEN1 (0.46) PRKCGPRKCAPRKCDKDM4E
SCHEMBL4110804 0.71 ALOX15 (0.42) PRKCGPRKCAPRKCDMAPTPTGS2
SCHEMBL8079998 0.71 KDM4E (0.34) PRKCGPRKCAPRKCDKDM4EMAPT
SCHEMBL3218240 0.71 HTR2A (0.45) KDM4EMAPTL3MBTL1
SCHEMBL14258253 0.71 HTT (0.39) PRKCGPRKCAPRKCDKDM4EMAPT
SCHEMBL59871 0.69
SCHEMBL1506627 0.69 PRKCG (0.31) PRKCGPRKCAPRKCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115353667-A Method and material for reducing waste 李蓁蓁 2022-11-18 CN disclosed
EP-2810943-B1 SITAXENTAN DERIVATIVE EISAI R&D MAN CO LTD (JP) 2017-09-27 EP disclosed
EP-2810943-B1 SITAXENTAN DERIVATIVE EISAI R&D MAN CO LTD (JP) 2017-09-27 EP disclosed
EP-2810943-A1 SITAXSENTAN DERIVATIVE Eisai R&D Management Co., Ltd. (JP) 2014-12-10 EP disclosed
EP-2810943-A1 SITAXSENTAN DERIVATIVE Eisai R&D Management Co., Ltd. (JP) 2014-12-10 EP disclosed
US-8642014-B2 Luminescent compounds SETA BIOMEDICALS, LLC (US) 2014-02-04 US disclosed
US-8642014-B2 Luminescent compounds SETA BIOMEDICALS, LLC (US) 2014-02-04 US disclosed
US-8642014-B2 Luminescent compounds SETA BIOMEDICALS, LLC (US) 2014-02-04 US disclosed
US-8592470-B2 Sitaxentan derivative EISAI R&D MANAGEMENT CO., LTD. (JP) 2013-11-26 US disclosed
US-20130197045-A1 SITAXENTAN DERIVATIVE EISAI R&D MANAGEMENT CO., LTD. (JP) 2013-08-01 US disclosed
US-20130197045-A1 SITAXENTAN DERIVATIVE EISAI R&D MANAGEMENT CO., LTD. (JP) 2013-08-01 US disclosed
US-20100266507-A1 LUMINESCENT COMPOUNDS SETA BIOMEDICALS, LLC 2010-10-21 US disclosed
US-20100266507-A1 LUMINESCENT COMPOUNDS SETA BIOMEDICALS, LLC 2010-10-21 US disclosed
US-20100266507-A1 LUMINESCENT COMPOUNDS SETA BIOMEDICALS, LLC 2010-10-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100266507-A1 LUMINESCENT COMPOUNDS SQLE, COASY, ZKSCAN2 PRKCG 412/4885PRKCA 469/4885PRKCD 1014/4885
US-20130197045-A1 SITAXENTAN DERIVATIVE CYP4A11, CYP11B1, HSD11B1 PRKCG 793/4885PRKCA 502/4885PRKCD 413/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.