Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.38 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.38 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.38 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.38 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.38 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3738688 | 0.99 | MAPT (0.47) | MAPTNOX1LMNAMAPK1TDP1 | |
| SCHEMBL30986852 | 0.80 | MAOA (0.41) | ALDH1A1TP53SMN1; SMN2GSK3BHPGD | |
| SCHEMBL12193903 | 0.80 | MAOA (0.41) | ALDH1A1TP53SMN1; SMN2GSK3BHPGD | |
| SCHEMBL3731249 | 0.77 | ALOX5 (0.35) | ALDH1A1TP53SMN1; SMN2GSK3BHPGD | |
| SCHEMBL27645758 | 0.75 | BCHE (0.39) | MAPTNOX1LMNAMAPK1TDP1 | |
| SCHEMBL19675523 | 0.70 | NOX1 (0.44) | MAPTNOX1LMNAMAPK1TDP1 | |
| SCHEMBL29023301 | 0.69 | KDM4E (0.43) | MAPTNOX1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL12264201 | 0.69 | MAOA (0.46) | NOX1L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL28131846 | 0.68 | NOX1 (0.42) | MAPTNOX1LMNAMAPK1TDP1 | |
| SCHEMBL17399090 | 0.68 | MYLK (0.38) | MAPTALDH1A1MEN1KMT2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1882602-A | Modulation and degradation of hyaluronan synthesis in the treatment of disease | MEDITECH RES LTD (AU) | 2006-12-20 | — | — | CN | claimed |
| CN-1761517-A | Mixing device | HENKEL KGAA (DE) | 2006-04-19 | — | — | CN | disclosed |