Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.50 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
| ▸ | FADS1 | O60427 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27639068 | 0.88 | TYK2 (0.57) | TYK2P2RX7P2RY12MAPTCLK1 | |
| SCHEMBL7984549 | 0.81 | TYK2 (0.62) | TYK2P2RX7P2RY12MAPTALDH1A1 | |
| SCHEMBL1180024 | 0.77 | KDM4E (0.60) | TYK2P2RX7P2RY12MAPTALDH1A1 | |
| SCHEMBL696853 | 0.75 | ALDH1A1 (0.59) | TYK2P2RX7P2RY12MAPTALDH1A1 | |
| SCHEMBL4261329 | 0.75 | SMN1; SMN2 (0.59) | TYK2MAPTALDH1A1SMN1; SMN2ERCC5 | |
| SCHEMBL1363543 | 0.75 | TYK2 (0.55) | TYK2P2RX7P2RY12MAPTALDH1A1 | |
| SCHEMBL2850887 | 0.74 | CASP1 (0.55) | TYK2P2RX7P2RY12MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL18861007 | 0.74 | SMN1; SMN2 (0.57) | TYK2MAPTALDH1A1SMN1; SMN2ERCC5 | |
| SCHEMBL27638945 | 0.73 | LMNA (0.62) | MAPTCLK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL31104526 | 0.72 | P2RX7 (0.56) | TYK2P2RX7P2RY12MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826333-B | Diamine derivatives | DAIICHI SANKYO CO LTD | 2012-12-26 | — | — | CN | disclosed |
| CN-100545160-C | Diamine derivative | DAIICHI SEIYAKU CO (JP) | 2009-09-30 | — | — | CN | disclosed |
| CN-1894238-A | Diamine derivatives | DAIICHI SEIYAKU CO (JP) | 2007-01-10 | — | — | CN | disclosed |
| CN-1826333-A | Diamine derivatives | DAIICHI SEIYAKU CO (JP) | 2006-08-30 | — | — | CN | disclosed |
| CN-1751025-A | Diamine derivatives | DAIICHI SEIYAKU CO (JP) | 2006-03-22 | — | — | CN | disclosed |
| CN-1745071-A | Novel ethylenediamine derivative | DAIICHI SEIYAKU CO (JP) | 2006-03-08 | — | — | CN | disclosed |