Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.30 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27620483 | 0.77 | L3MBTL1 (0.42) | NPC1MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL27720610 | 0.72 | HCAR3 (0.43) | — | |
| SCHEMBL27987021 | 0.71 | STK17B (0.42) | ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL27987019 | 0.71 | STK17B (0.42) | ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL27865070 | 0.69 | KMT2A (0.44) | RAB9ANPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL27987449 | 0.69 | ESR1 (0.33) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL889066 | 0.68 | NPC1 (0.54) | RAB9ANPC1PCSK9ACACBMEN1 | |
| SCHEMBL23320696 | 0.67 | RAB9A (0.41) | RAB9ANPC1KDM4EALDH1A1HDAC3 | |
| SCHEMBL2068114 | 0.66 | NPC1 (0.50) | RAB9ANPC1ACACBMEN1KMT2A | |
| SCHEMBL20714561 | 0.65 | NPC1 (0.47) | RAB9ANPC1PCSK9ACACBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100448874-C | N-aroyl cyclic amines | SMITHKLINE BEECHAM PLC (GB) | 2009-01-07 | — | — | CN | disclosed |
| CN-1633433-A | N-aroyl cyclic amines | SMITHKLINE BEECHAM PLC (GB) | 2005-06-29 | — | — | CN | disclosed |