Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.36 |
| ▸ | CES1 | P23141 | 4/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | LDHB | P07195 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10580660 | 0.82 | MAPT (0.47) | ADORA1MAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4359910 | 0.74 | KDM4E (0.40) | ADORA2AADORA1MAPTKDM4EALDH1A1 | |
| SCHEMBL932304 | 0.72 | — | — | |
| SCHEMBL7209768 | 0.71 | IKBKB (0.41) | ADORA2AADORA1MAPTATMKDM4E | |
| SCHEMBL10476788 | 0.70 | CES2 (0.59) | CES2CES1MAPTLMNANPSR1 | |
| SCHEMBL6822743 | 0.70 | CTNNB1 (0.59) | ATMALDH1A1MAPK1CTNNB1WNT3A | |
| SCHEMBL3485241 | 0.68 | PARP1 (0.47) | MAPTLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL761381 | 0.66 | CES2 (0.65) | CES2CES1MAPTLMNANPSR1 | |
| SCHEMBL21223630 | 0.65 | KDM3B (0.33) | KDM4ECSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL10476789 | 0.64 | CES2 (0.67) | CES2CES1MAPTLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1646141-B | Modified nucleosides for treating viral infections and abnormal cell proliferation | PHARMASSET LTD | 2014-06-25 | — | — | CN | disclosed |
| CN-101862345-B | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation | GILEAD SCIENCES INC | 2014-06-04 | — | — | CN | disclosed |
| CN-101862345-A | The modified nucleosides that is used for the treatment of viral infection and abnormal cell proliferation | PHARMASSET LTD | 2010-10-20 | — | — | CN | disclosed |
| CN-1646141-A | Modified nucleosides for treating viral infections and abnormal cell proliferation | PHARMASSET LTD (BB) | 2005-07-27 | — | — | CN | disclosed |