SCHEMBL932304

SCHEMBL932304

C=C(I)c1c[nH]c(=O)nc1N

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL532660 0.81
SCHEMBL3817207 0.81
SCHEMBL7209768 0.77 IKBKB (0.41)
SCHEMBL4359910 0.77 KDM4E (0.40)
SCHEMBL28361145 0.76 PBRM1 (0.38)
SCHEMBL27622347 0.72 CES2 (0.36)
SCHEMBL65897 0.70
SCHEMBL10580660 0.69 MAPT (0.47)
SCHEMBL5143009 0.69
SCHEMBL21223630 0.67 KDM3B (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110245479-A1 Method for Generating Aptamers with Improved Off-Rates SOMALOGIC, INC. (US) 2011-10-06 US claimed
EP-2069529-A2 METHOD FOR GENERATING APTAMERS WITH IMPROVED OFF-RATES Somalogic, Inc. (US) 2009-06-17 EP claimed
WO-2009012418-A2 METHOD FOR GENERATING APTAMERS WITH IMPROVED OFF-RATES SOMALOGIC, INC. (US) 2009-01-22 WO claimed
US-20090004667-A1 METHOD FOR GENERATING APTAMERS WITH IMPROVED OFF-RATES SOMALOGIC, INC. (US) 2009-01-01 US claimed
EP-1994171-A2 MULTIPLEXED ANALYSES OF TEST SAMPLES SomaLogic, Inc. (US) 2008-11-26 EP claimed
EP-1889910-A2 Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex SomaLogic, Inc. (US) 2008-02-20 EP claimed
EP-0736105-B1 SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: PHOTOSELECTION OF NUCLEIC ACID LIGANDS SOMALOGIC INC (US) 2007-11-21 EP claimed
WO-2007084886-A2 MULTIPLEXED ANALYSES OF TEST SAMPLES SOMALOGIC, INCORPORATED (US) 2007-07-26 WO claimed
US-20070166740-A1 MULTIPLEXED ANALYSES OF TEST SAMPLES SOMALOGIC, INCORPORATED (US) 2007-07-19 US claimed
US-20070166741-A1 MULTIPLEXED ANALYSES OF TEST SAMPLES SOMALOGIC, INCORPORATED (US) 2007-07-19 US claimed
US-20040132067-A1 Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex SOMALOGIC, INC. 2004-07-08 US claimed
US-20030054360-A1 Method and apparatus for the automated generation of nucleic acid ligands SOMALOGIC, INC. 2003-03-20 US claimed
US-6482594-B2 Made by exposing nucleic acid candidate sequences having photoreactive groups to the target molecule, irradiating complexes formed to crosslink, and separating the crosslinked complexes and amplifying to give the ligands SOMALOGIC, INC. 2002-11-19 US claimed
WO-2002077262-A2 METHOD AND APPARATUS FOR THE AUTOMATED GENERATION OF NUCLEIC ACID LIGANDS SOMALOGIC, INC. (US) 2002-10-03 WO claimed
US-20020106652-A1 Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex SOMALOGIC, INC. 2002-08-08 US claimed
US-6001577-A SCREENING FOR LIGANDS ASSOCIATED WITH A DISEASE BY DETECTING LIGAND THAT PHOTOCROSSLINKS TO TARGET WITH PHOTOREACTIVE GROUPS FROM CANDIDATE MIXTURE, REMOVING ANY NUCLEIC ACIDS WITH AFFINITIES NOT ASSOCIATED WITH DISEASE, AND AMPLIFYING NEXSTAR PHARMACEUTICALS, INC. (US) 1999-12-14 US claimed
EP-0736105-A4 SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: PHOTOSELECTION OF NUCLEIC ACID LIGANDS AND SOLUTION SELEX UNIV RESEARCH CORP (US) 1998-10-28 EP claimed
US-5763177-A SELEX IS AN ACRONYM FOR SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT; USEFUL FOR DIAGNOSIS AND/OR TREATMENT OF DISEASES OR PATHOLOGICAL OR TOXIC STATES NEXSTAR PHARMACEUTICALS, INC. (US) 1998-06-09 US claimed
EP-0736105-A1 SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: PHOTOSELECTION OF NUCLEIC ACID LIGANDS AND SOLUTION SELEX NeXstar Pharmaceuticals, Inc. (US) 1996-10-09 EP claimed
WO-1995008003-A1 SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: PHOTOSELECTION OF NUCLEIC ACID LIGANDS AND SOLUTION SELEX UNIVERSITY RESEARCH CORPORATION (US) 1995-03-23 WO claimed