Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.32 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL28229779 | 0.97 | ALDH1A1 (0.59) | ALDH1A1TDP1HIF1AMAPTPDE4A | |
| Piperazine SCHEMBL28047208 | 0.82 | FFAR3 (0.56) | ALDH1A1TDP1HIF1AMAPTPDE4A | |
| Piperazine SCHEMBL27871604 | 0.81 | TDP1 (0.62) | ALDH1A1TDP1HIF1AMAPTPDE4A | |
| Piperazine SCHEMBL5818604 | 0.81 | FFAR3 (0.62) | ALDH1A1TDP1HIF1AMAPTPDE4A | |
| Piperazine SCHEMBL28214068 | 0.81 | FFAR3 (0.62) | ALDH1A1TDP1HIF1AMAPTPDE4A | |
| Piperazine SCHEMBL2429468 | 0.79 | LMNA (0.50) | HIF1AMAPTPDE4AKDRFFAR3 | |
| Butanone SCHEMBL1510153 | 0.79 | — | — | |
| Butanone SCHEMBL1039820 | 0.79 | ALDH1A1 (1.00) | ALDH1A1TDP1FFAR3TRPA1TSHR | |
| Butanone SCHEMBL8379087 | 0.79 | ALDH1A1 (1.00) | ALDH1A1TDP1FFAR3TRPA1TSHR | |
| Butanone SCHEMBL27495689 | 0.79 | ALDH1A1 (1.00) | ALDH1A1TDP1FFAR3TRPA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1780611-B | Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer | PURDUE PHARMA LTD | 2013-01-30 | — | — | CN | disclosed |
| CN-1780611-A | Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer | PURDUE PHARMA LTD (US) | 2006-05-31 | — | — | CN | disclosed |