Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27974004 | 0.85 | — | — | |
| SCHEMBL28016518 | 0.81 | EPHX2 (0.36) | TP53TSHRSMN1; SMN2 | |
| SCHEMBL27701075 | 0.76 | CNR2 (0.33) | TP53ALDH1A1ATM | |
| SCHEMBL27932514 | 0.76 | CYP1A2 (0.38) | ALDH1A1KDM4EHTTLMNATDP1 | |
| SCHEMBL27596966 | 0.76 | CTSK (0.35) | SMN1; SMN2 | |
| SCHEMBL8431323 | 0.76 | HPGD (0.33) | ALDH1A1SMN1; SMN2MAPTHTTKMT2A | |
| SCHEMBL27849882 | 0.75 | GNAI3 (0.30) | — | |
| SCHEMBL8433485 | 0.74 | HPGD (0.36) | ALDH1A1SMN1; SMN2MAPTHTTKMT2A | |
| SCHEMBL27758892 | 0.74 | HPGD (0.36) | ALDH1A1SMN1; SMN2MAPTHTTKMT2A | |
| SCHEMBL28060488 | 0.73 | CYP1A2 (0.45) | ALDH1A1SMN1; SMN2KDM4ETDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1738814-A | Indolyl pyrazinone derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER PHARMACEUTICALS CORP (US) | 2006-02-22 | — | — | CN | disclosed |