Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 4/20 | 0.47 |
| ▸ | CES1 | P23141 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3589894 | 0.88 | ALDH1A1 (0.54) | ALOX5FAAHCES1KDM4E | |
| SCHEMBL3055621 | 0.86 | ALOX5 (0.48) | ALOX5FAAHCES1KDM4ELMNA | |
| SCHEMBL27568458 | 0.86 | ALOX5 (0.55) | ALOX5FAAHCES1KDM4ELMNA | |
| SCHEMBL3076222 | 0.80 | KDM4E (0.62) | ALOX5KDM4ELMNACYP1A2POLB | |
| SCHEMBL3589756 | 0.79 | LMNA (0.51) | ALOX5KDM4ELMNA | |
| Hexane SCHEMBL8813158 | 0.79 | FAAH (0.49) | FAAHCES1 | |
| SCHEMBL30387679 | 0.72 | KDM4E (0.50) | ALOX5KDM4ELMNACYP1A2POLB | |
| SCHEMBL5224048 | 0.72 | NPC1 (0.64) | ALOX5KDM4ELMNACYP1A2POLB | |
| SCHEMBL624039 | 0.71 | PIK3CA (0.55) | ALOX5KDM4ELMNACYP1A2POLB | |
| SCHEMBL14999169 | 0.71 | PDE4A (0.46) | ALOX5KDM4ELMNACYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100343256-C | Biaryl substituted diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2007-10-17 | — | — | CN | claimed |
| CN-1678615-A | Biaryl substituted diazabicycloalkanes as nicotinic acetylcholine antagonists | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | CN | claimed |
| CN-100343256-C | Biaryl substituted diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2007-10-17 | — | — | CN | disclosed |
| CN-1678615-A | Biaryl substituted diazabicycloalkanes as nicotinic acetylcholine antagonists | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | CN | disclosed |