Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27643471 | 0.81 | MAPK14 (0.38) | KMT2AL3MBTL1ALDH1A1CYP1A2GAA | |
| SCHEMBL6842163 | 0.79 | KMT2A (0.48) | KMT2AL3MBTL1ALDH1A1CYP1A2GAA | |
| SCHEMBL27815709 | 0.77 | L3MBTL1 (0.40) | KMT2AL3MBTL1ALDH1A1CYP1A2GAA | |
| SCHEMBL27624143 | 0.75 | KMT2A (0.42) | KMT2AL3MBTL1ALDH1A1CYP1A2GAA | |
| SCHEMBL27594748 | 0.74 | ALDH1A1 (0.44) | KMT2AALDH1A1CYP1A2GAARAB9A | |
| SCHEMBL27711076 | 0.70 | PPARD (0.32) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL4395319 | 0.69 | ALDH1A1 (0.66) | KMT2AL3MBTL1ALDH1A1CYP1A2GAA | |
| SCHEMBL27634019 | 0.68 | RAB9A (0.58) | KMT2AL3MBTL1ALDH1A1CYP1A2GAA | |
| SCHEMBL8554963 | 0.68 | ALDH1A1 (0.55) | KMT2AL3MBTL1ALDH1A1CYP1A2GAA | |
| SCHEMBL1592594 | 0.68 | RXFP1 (0.62) | KMT2AL3MBTL1ALDH1A1CYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112010844-A | Preparation method and application of N- (pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor | 中国药科大学 | 2020-12-01 | — | — | CN | disclosed |
| CN-103524442-A | Pyrimidine compound, triazine compound and application thereof as medicine | LE SUN PHARMACEUTICALS LTD | 2014-01-22 | — | — | CN | disclosed |
| CN-102143953-B | Pyrimidines, triazines and their use as pharmaceutical agents | LE SUN PHARMACEUTICALS LTD | 2013-12-25 | — | — | CN | disclosed |
| CN-102143953-A | Pyrimidines, triazines and their use as pharmaceutical agents | UNIV NOTTINGHAM | 2011-08-03 | — | — | CN | disclosed |
| CN-100415740-C | Pyrimidine compounds | CYCLACEL LTD (GB) | 2008-09-03 | — | — | CN | disclosed |
| CN-1711258-A | Pyrimidine compounds | CYCLACEL LTD (GB) | 2005-12-21 | — | — | CN | disclosed |