Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | GPR183 | P32249 | 5/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27736334 | 0.86 | USP2 (0.38) | CYP1A2MAOBPTGES2 | |
| SCHEMBL27361620 | 0.86 | CYP11B1 (0.37) | GPR183LMNAMAOBKCNH2 | |
| SCHEMBL27756903 | 0.82 | CYP1A2 (0.41) | CYP1A2GPR183LMNAGABRA1GABRG2 | |
| SCHEMBL27736309 | 0.80 | PYGL (0.42) | GRIK1GRIK2 | |
| SCHEMBL27469722 | 0.79 | SLC6A2 (0.43) | KCNH2 | |
| SCHEMBL28963985 | 0.78 | GPR183 (0.40) | GPR183GRIK1GRIK2LMNAKCNH2 | |
| SCHEMBL28779017 | 0.76 | CYP1A2 (0.42) | CYP1A2GRIK1GRIK2LMNAMAOB | |
| SCHEMBL27587931 | 0.72 | MAPK1 (0.30) | LMNA | |
| SCHEMBL27523653 | 0.69 | GPR183 (0.50) | CYP1A2GPR183TSHRKCNH2SMN1; SMN2 | |
| SCHEMBL5212189 | 0.68 | MAPK1 (0.41) | LMNACYP3A4GABRA1TSHRGABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528684-A | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine h3-receptor useful for the treatment of disorders related thereto | ARENA PHARM INC (US) | 2009-09-09 | — | — | CN | disclosed |
| CN-1787997-A | 4-arylsulphonylpiperidine derivatives for antagonism of the 5-HT2A receptor | MERCK SHARP & DOHME (GB) | 2006-06-14 | — | — | CN | disclosed |