Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27736334 | 0.84 | USP2 (0.38) | CYP1A2NFE2L2MAOB | |
| SCHEMBL27736309 | 0.83 | PYGL (0.42) | ALDH1A1GRIK1GRIK2 | |
| SCHEMBL27469722 | 0.80 | SLC6A2 (0.43) | — | |
| SCHEMBL27613818 | 0.77 | USP2 (0.47) | CYP1A2CYP2C9DRD2NFE2L2MAOB | |
| SCHEMBL27625548 | 0.76 | CYP1A2 (0.36) | CYP1A2MAOBLMNACYP2D6CYP1B1 | |
| SCHEMBL27361620 | 0.76 | CYP11B1 (0.37) | MAOBALDH1A1LMNAKMT2A | |
| SCHEMBL27611669 | 0.74 | CYP1A2 (0.50) | CYP1A2CYP2C9NFE2L2MAOBMAOA | |
| SCHEMBL27756903 | 0.73 | CYP1A2 (0.41) | CYP1A2MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL27611377 | 0.73 | HTR6 (0.59) | — | |
| SCHEMBL2719157 | 0.72 | CYP1A2 (0.47) | CYP1A2CYP2C9DRD2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101400653-A | 11-beta HSD1 inhibitors | WYETH CORP (US) | 2009-04-01 | — | — | CN | disclosed |