Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27692435 | 0.98 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAL3MBTL1TBXAS1CFTR | |
| SCHEMBL28803513 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAL3MBTL1TBXAS1CFTR | |
| Hydrochloric Acid SCHEMBL27645555 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAL3MBTL1TBXAS1CFTR | |
| SCHEMBL235125 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAL3MBTL1TBXAS1CFTR | |
| SCHEMBL29852444 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAL3MBTL1TBXAS1CFTR | |
| SCHEMBL6075149 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAL3MBTL1CFTRSLC6A2 | |
| SCHEMBL6307776 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAL3MBTL1CFTRSLC6A2 | |
| SCHEMBL27561149 | 0.77 | LMNA (0.42) | SMN1; SMN2LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4476838 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAL3MBTL1CFTRSLC6A2 | |
| SCHEMBL29963731 | 0.77 | TBXAS1 (0.47) | SMN1; SMN2LMNAL3MBTL1TBXAS1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110225912-A | GSK-3 inhibitor | 百时美施贵宝公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-104781254-B | Can as kinase modulator through the substituted pyridinyl compounds of heteroaryl | 百时美施贵宝公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-103342701-B | Thiazolamine compound polymorphic as inhibitors of kinases and preparation method thereof | AB科学有限公司 | 2016-09-21 | — | — | CN | disclosed |
| CN-104093308-A | Pesticidal compositions and processes related thereto | DOW AGROSCIENCES LLC | 2014-10-08 | — | — | CN | disclosed |
| CN-103957908-A | Substituted aminothiazoles as inhibitors of cancer including hepatocellular carcinoma and as inhibitors of hepatitis virus replication | INST HEPATITIS & VIRUS RES | 2014-07-30 | — | — | CN | disclosed |
| CN-103342701-A | 2-Aminothiazole compound polycrystalline type as kinase inhibitors and preparation method thereof | AB SCIENCE | 2013-10-09 | — | — | CN | disclosed |
| CN-101657446-B | Method for synthesizing 2-aminothiazole compounds as kinase inhibitors | AB SCIENCE | 2013-05-15 | — | — | CN | disclosed |
| CN-101679404-B | Piperidine-amide derivatives | HOFFMANN LA ROCHE | 2012-06-13 | — | — | CN | disclosed |
| CN-102123987-A | Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds | GILEAD COLORADO INC | 2011-07-13 | — | — | CN | disclosed |
| CN-101006082-B | Histamine H3 receptor agents, methods of preparation and therapeutic uses | LILLY CO ELI | 2010-09-29 | — | — | CN | disclosed |
| CN-101679404-A | piperidine-amide derivatives | HOFFMANN LA ROCHE | 2010-03-24 | — | — | CN | disclosed |
| CN-101657446-A | Method for synthesizing 2-aminothiazole compounds as kinase inhibitors | SCIENCE FR AB | 2010-02-24 | — | — | CN | disclosed |
| CN-100381429-C | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2008-04-16 | — | — | CN | disclosed |
| CN-101006082-A | Histamine H3 receptor agents, methods of preparation and therapeutic uses | LILLY CO ELI (US) | 2007-07-25 | — | — | CN | disclosed |
| CN-1980906-A | Compounds and compositions as PPAR modulators | IRM LLC (BM) | 2007-06-13 | — | — | CN | disclosed |
| CN-1930144-A | 3-'4-heterocyclyl -1,2,3,-triazol-1-yl!-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases | BOEHRINGER INGELHEIM PHARMA (US) | 2007-03-14 | — | — | CN | disclosed |
| CN-1675188-A | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | CN | disclosed |