Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CATSPER1 | Q8NEC5 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996654 | 0.81 | ALDH1A1 (0.57) | ALDH1A1PTPN1SRD5A2MAPTKMT2A | |
| SCHEMBL8800218 | 0.79 | BRD4 (0.50) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4054650 | 0.77 | PTGS1 (0.44) | ALDH1A1PTPN1SRD5A2MAPTKMT2A | |
| SCHEMBL27365043 | 0.74 | CATSPER1 (0.40) | ALDH1A1PTPN1SRD5A2MAPTKMT2A | |
| SCHEMBL4054647 | 0.70 | PTPN1 (0.41) | ALDH1A1PTPN1SRD5A2MAPTKMT2A | |
| SCHEMBL280055 | 0.69 | PTPN1 (0.54) | ALDH1A1PTPN1MAPTKMT2AMEN1 | |
| SCHEMBL15891186 | 0.69 | ALDH1A1 (0.56) | ALDH1A1SRD5A2MAPTKMT2AMEN1 | |
| SCHEMBL8463065 | 0.68 | PTGS2 (0.56) | ALDH1A1SRD5A2MAPTKMT2AMEN1 | |
| SCHEMBL28533570 | 0.67 | ALDH1A1 (0.68) | ALDH1A1SRD5A2MAPTKMT2AMEN1 | |
| SCHEMBL28678655 | 0.67 | ALDH1A1 (0.68) | ALDH1A1SRD5A2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1976904-A | Pyridazin-3 (2H) -one derivatives and their use as PDE4 inhibitors | ALMIRALL LAB (ES) | 2007-06-06 | — | — | CN | disclosed |
| CN-1668603-A | Pyridazin-3(2h)-one derivatives as PDE4 inhibitors | ALMIRALL PRODESFARMA SA (ES) | 2005-09-14 | — | — | CN | disclosed |