Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | CATSPER1 | Q8NEC5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27622444 | 0.88 | SRD5A2 (0.52) | ALDH1A1GAALMNAMAPTRECQL | |
| SCHEMBL5211761 | 0.87 | LMNA (0.47) | ALDH1A1GAALMNAMAPTRECQL | |
| SCHEMBL27622448 | 0.86 | POLB (0.51) | ALDH1A1GAALMNAMAPTRECQL | |
| SCHEMBL27627423 | 0.85 | LMNA (0.46) | ALDH1A1GAALMNAMAPTRECQL | |
| SCHEMBL27627404 | 0.84 | CYP1A2 (0.48) | ALDH1A1GAALMNAMAPTRECQL | |
| SCHEMBL6175924 | 0.83 | CA1 (0.50) | ALDH1A1GAALMNAMAPTRECQL | |
| SCHEMBL27622437 | 0.83 | ALDH1A1 (0.47) | ALDH1A1GAALMNAMAPTRECQL | |
| SCHEMBL1323891 | 0.82 | ALDH1A1 (0.60) | ALDH1A1GAALMNAMAPTKMT2A | |
| SCHEMBL994810 | 0.82 | HTT (0.54) | ALDH1A1GAALMNAMAPTTSHR | |
| SCHEMBL27641421 | 0.81 | LMNA (0.46) | ALDH1A1GAALMNAMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125830-B1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL SA (ES) | 2011-01-26 | — | — | EP | claimed |
| EP-2125830-B1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL SA (ES) | 2011-01-26 | — | — | EP | disclosed |
| EP-2125830-B1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL SA (ES) | 2011-01-26 | — | — | EP | disclosed |
| US-20100137591-A1 | PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO [3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL, S.A. (ES) | 2010-06-03 | — | — | US | disclosed |
| EP-2125830-A1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLOÝ3,4-D¨PYRIDAZIN-7(6H)-ONE | Almirall, S.A. (ES) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008107064-A1 | NEW PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONE | ALMIRALL S.A. (ES) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137591-A1 | PROCESS FOR PREPARING 3-METHYL-4-PHENYLISOXAZOLO [3,4-D]PYRIDAZIN-7(6H)-ONE | HPD, CYP4F11, CYP4F8 | ALDH1A1 215/4885GAA 3073/4885LMNA 2237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.